Heplisav-B Hepatitis B Vaccine (Recombinant), Adjuvanted is the first US licensed vaccine for manufacturer Dynavax.  This HepB-CpG vaccine was approved by the FDA in October 2017. It is indicated for patients 18 years of age and older and is only 2 doses.  ACIP recommendations may be read here in the April 20th, 2018 MMWR.  National Vaccine expert Dr. Paul Offit shares a quick review of this new hepatitis B vaccine here.